I guess it depends on the size of the estate and what the split to the children will do for them.
If it's enough to substantially set them up, then why not help as many others a possible with the remainder.
Bloodline Trust to our kids when they're post 25 years old.
If we're all whipped out, 50/50 sister & bro-in-law.
If they're whipped out, divided equally between nephews & nieces.